Glutathione becomes inactive when it becomes saturated from doing its work of collecting free radicals, but it tends to regenerate itself in a healthy liver. Under ideal conditions, 10% of the glutathione remains inactive (or oxidized), while the other 90% is active. As the active glutathione (also known as GSH), drops below 90% and allows the inactive to increase beyond 10%, the struggle for optimum health begins to become a losing battle.